Modernizing Clinical Trial Design and Analysis to Improve Efficiency & Flexibility

RCT
drug-development
bayes
regression
endpoints
This presentation covers several ways to make clinical trials more efficient and to reduce the chance of ending with an equivocal result. Some of the approaches covered are Bayesian sequential designs allowing for study extension if results are promising, not being tied by type I assertion probabilities/α spending, using high-information longitudinal ordinal outcomes, and covariate adjustment.
Author

Frank Harrell

Published

March 14, 2024